김은주 사진

김은주 | 자연과학대학 분자생물학과 (자연과학2관)

  • 직급:
    교수

학력

  • [1999] 석사 가톨릭대학교(성의교정) / 의생물과학 / 의생물과학
  • [2002] 박사 가톨릭대학교(성의교정) / 의생물과학 / 의생물과학

주요경력

  • Johns Hopkins University (2002-08-19)

주요연구분야

암과 노화의 후성유전학적 조절 연구
노화 관련 질환 연구

컨설팅 가능 분야

암 및 노화 제어 기반기술 개발
암 및 노화의 후성유전학적 치료기술 개발

연구업적

  • 연구보고서[20120620] PcG(Polycomb protein)과 SIRTI 조절에 의한 세포노화 억제(3/3)
  • 일반논문[20230601] SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence
  • 일반논문[20230401] Shikonin Binds and Represses PPARγ Activity by Releasing Coactivators and Modulating Histone Methylation Codes
  • 일반논문[20220801] Kaempferol antagonizes adipogenesis by repressing histone H3K4 methylation at PPAR? target genes
  • 일반논문[20200201] SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells
  • 일반논문[20190901] Piperine inhibits adipocyte differentiation via dynamic regulation of histone modifications
  • 일반논문[20190115] Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal
  • 일반논문[20181102] Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis
  • 일반논문[20180701] 단백질 아르기닌 메틸전이효소 5(PRMT5)에 의한 3T3L-1 세포의 지방세포 분화 조절
  • 일반논문[20180501] Effects of the generated functional groups by PECVD on adhesiveness of adipose derived mesenchymal stem cells
  • 일반논문[20180101] RaRF confers RA resistance by sequestering RAR to the nucleolus and regulating MCL1 in leukemia cells
  • 일반논문[20171201] CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPAR gamma and inhibit adipogenesis
  • 일반논문[20170701] Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation
  • 일반논문[20170601] Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells
  • 일반논문[20160714] ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation.
  • 일반논문[20160413] CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells
  • 일반논문[20160122] CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells
  • 일반논문[20151023] Role of Asxl1 in kidney podocyte development via its interaction with Wtip
  • 일반논문[20140221] De-repression of RaRF-mediated RAR repression by adenovirus E1A in the nucleolus
  • 일반논문[20140110] Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis
  • 일반논문[20130728] CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.
  • 일반논문[20130605] Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells.
  • 일반논문[20130501] Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.
  • 일반논문[20130104] Negative regulation of ERa by a novel protein CAC1 through association with histone demethylase LSD1
  • 일반논문[20121012] CAC1 negatively regulates RARa activity through cooperation with HDAC
  • 일반논문[20120901] Negative Regulation of Adipogenesis by Kaempferol, a Component of Rhizoma Polygonati falcatum in 3T3-L1 Cells
  • 일반논문[20120511] Positive regulation of additional sex comb-like 1 gene expression by the pluripotency factor SOX2
  • 일반논문[20120418] Piperine,a Component of Black Pepper, Inhibits Adipogenesis by Antagonizing PPARγ Activity in 3T3-L1 Cells
  • 일반논문[20120210] Negative regulation of ERRα by a novel nucleolar protein
  • 일반논문[20110114] Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of PPAR{gamma}
  • 일반논문[20110107] PTOV1 antagonizes MED25 in RAR transcriptional activation.
  • 일반논문[20091211] Redox regulation of transcriptional activity of retinoic acid receptor by thioredoxin glutathione reductase (TGR)
  • 일반논문[20090201] Kinase activity-independent suppression of p73 alpha by AMP-activated kinase alpha (AMPK alpha)
  • 일반논문[20081219] Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins
  • 일반논문[20081219] Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1
  • 일반논문[20081130] SIRT1: roles in aging and cancer
  • 일반논문[20080930] SIRT1:A Key link between cancer and aging
  • 지식재산권[20171106] CACUL1 단백질을 포함하는 전립선암의 예방 또는 치료용 약학 조성물(A pharmaceutical composition for preventing or treating prostate cancer comprising CACUL1 protein)
  • 지식재산권[20151019] CACUL1 단백질을 포함하는 전립선암의 예방 또는 치료용 약학 조성물
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