고선일 사진

고선일 | 치과대학 치의예과 (치의학관, 치과대학병원)

  • 직급:
    교수

교수소개

구강생화학을 전공하였으며, 2000년 3월 단국대학교 치과대학에 전임으로 발령 받아 치과생화학 및 실험, 구강생화학 및 실험등을 강의하고 있다.
골조직 대사에 영향을 미치는 물질에 관한 연구를 수행하고 있으며, 이를 통하여 치주질환을 포함한 뼈파괴질환의 개선 등의 효능을 가지는 물질을 발굴하는데 관심을 가지고 있다.

교육철학

수업을 통해 단순한 지식만의 전달이 아니라 수업내용을 이해하여 문제를 해결할 수 있고, 합리적인 생각을 할 수 있도록 교육하고자 한다.

학력

  • [1992] 학사 단국대학교 / 치의학
  • [1994] 석사 단국대학교 / 치의학 / 구강생화학
  • [1998] 박사 단국대학교 / 치의학 / 구강생화학

주요연구분야

Bone formation
Drug development for osteoporosis
Effects of tumors on the skeleton
Osteoclast biology

컨설팅 가능 분야

Cell culture employing cell lines and primary cells including the
culture of murine bone marrow stromal cells, for use the
assessment of osteoclast formation and bone resorption

연구업적

  • 일반논문[20221201] Cell Surface Accumulation of Intracellular Leucine Proline-Enriched Proteoglycan 1 Enhances Odontogenic Potential of Human Dental Pulp Stem Cells
  • 일반논문[20191201] Effects of plant-derived natural products on inflammatory bone destructive disease
  • 일반논문[20181101] The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis
  • 일반논문[20170501] A monoclonal antibody recognizes undifferentiation-specific carbohydrate moieties expressed on cell surface of the human dental pulp cells
  • 일반논문[20161201] Inhibitory Effect of Myricetin on Matrix Metalloproteinase Expression and Activity in Periodontal Inflammation
  • 일반논문[20130630] The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
  • 일반논문[20121201] Myricetin suppresses LPS-induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW264.7 cells
  • 일반논문[20111101] n-Butanol extracts of Panax notoginseng suppress LPS-induced MMP-2 expression in periodontal ligament fibroblasts and inhibit osteoclastogenesis by suppressing MAPK in LPS-activated RAW264 7 cells
  • 일반논문[20110901] Microtubule Assembly Affects Bone Mass by Regulating Both Osteoblast and Osteoclast Functions: Stathmin Deficiency Produces an Osteopenic Phenotype in Mice
  • 일반논문[20110609] Transcriptional Regulation of BMP2 Expression by the PTH-CREB Signaling Pathway in Osteoblasts
  • 일반논문[20110301] Dentinogenic potential of human adult dental pulp cells during the extended primary culture
  • 일반논문[20100930] Luteolin Induces the Differentiation of Osteoblasts
  • 일반논문[20090301] Inhibition of Microtubule Assembly in Osteoblasts Stimulates Bone Morphogenetic Protein 2 Expression and Bone Formation through Transcription Factor Gli2
  • 일반논문[20070331] OPB, a water extract from Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max, inhibits osteoclast differentiation and function
  • 일반논문[20070331] Magnetofection is an efficient tool for ectopic gene expression into oral cells
  • 일반논문[20070126] Regulation of Polo-like Kinase 1 by DNA Damage in Mitosis INHIBITION OF MITOTIC PLK-1 BY PROTEIN PHOSPHATASE 2A
  • 일반논문[20060223] Effects of mushroom, Pleurotus eryngii, extracts on bone metabolism
  • 일반논문[20050801] Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice
  • 일반논문[20050630] Effects of Achyranthes Radix extracts on osteoblasts and osteoclasts
  • 일반논문[20041231] Immunoregulatory effects of extracts from the stem bark of Alkizzia julibrissin Durazz
  • 일반논문[20021230] Effects of genistein and ipriflavone on the proliferation and activity of bone cells
  • 저서/역서[20070215] 구강생화학 (Oral Biochemistry)
  • 지식재산권[20070202] 숙지황과 오가피의 혼합 생약재 추출물 및 이를 유효성분으로 하는 골다공증 예방 및 치료용 조성물
  • 학술발표[20130519] Myricetin suppress LPS-induced MMP expression in human periodontal ligament fibroblasts and inhibit osteoclastogenesis by downregulating NFATc1 in LPS-induced RAW 264.7 cells
  • 학술발표[20120830] Difference of orofacial thermal sensation between umpleasantness and pain to cold and hot stimuli
  • 학술발표[20120520] Myricetin suppress LPS-induced MMP expresion in human gingival fibroblasts and inhibit osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW264.7 cells
  • 학술발표[20110509] Baicalin inhibit osteoclastogenesis by suppressing MAPK and downregulating NFATc1 in RANKL-induced RAW264.7 cells
  • 학술발표[20110508] The CREB transcription factor regulates bone mass in humans and mice, activates BMP2 and contributes to PTH action in osteoblasts
  • 학술발표[20101126] Dentinogenic potential of human adult dental pulp cells during the extended primary culture
  • 학술발표[20101018] Contributions of PTH-mediator CREB to Postnatal Bone Mass in Human and Mouse Through Regulation of Osteoblast Function
  • 학술발표[20100628] n-butanol extracts of Panax notoginseng inhibit osteoclatogenesis by suppressing MAPK and downregulating NFATc1 and cFOS in LPS-activated RAW 264.7 cells
  • 학술발표[20090912] Deficiency of microtubule regulating protein stathmin reduces bone mass in mice by inhibiting BMP2 expression in osteoblasts
  • 학술발표[20080915] Calcium Signaling Is a Major Target of OCT-1547, a Small Molecule Osteoporosis Drug Candidate
  • 학술발표[20080914] Mechanism of Action of the Anti-Aging Agent Resveratrol on bone
  • 학술발표[20070917] Small Molecule Inducer of Activated CD4+ T Cell Death Inhibits Disease Progression in Collagen-induced Arthritis Models
  • 학술발표[20070917] OCT-1547, a Small Molecule Osteoporosis Drug Candidate, Inhibits Osteoclast Differentiation Through Inhibition of PLCγ2 Activation and NFATc1 Induction
  • 학술발표[20060915] Small Molecule Stimulators of Osteoprotegerin Secretion Inhibits Bone Destruction in Collagen-Induced Arthritis Models
  • 학술발표[20011012] Effects of Two Herbal Extracts on the Bone Metabolism
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