이환규 사진

이환규 | 공과대학 화학공학과 (제3공학관)

  • 직급:
    교수

교수소개

Homepage: https://sites.google.com/view/dkubiophysics

분자모델링 (Multiscale molecular dynamics simulation) 기법을 이용하여, 신약개발, 에너지, 나노재료/소재/센서 개발에 관한 연구를 수행. 특히, 나노파티클, 프로틴, 폴리머등 으로 구성된 복합체와 멤브레인과의 상호작용을 이해하고, 그들의 어플리케이션을 위한 최적 상태를 디자인.

학력

  • [2001] 학사 중앙대학교 / 화학공학과
  • [2004] 석사 Univ. of Michigan / Biomedical Engineering (Molecular Modelin
  • [2007] 박사 Univ. of Michigan / Biomedical Engineering (Molecular Modelin / Biophysics, Nanoscience, Polymer physics

주요연구분야

고분자 이론
바이오센서 개발
약물전달체 개발
합성생물학

컨설팅 가능 분야

분자모델링, 전산화학, 화학정보학
의약화학, 신약 개발, 약물전달체 개발
Polymer 구조 및 물성

연구업적

  • 연구보고서[20140212] 열감응성 리포좀 MD simulation
  • 일반논문[20240131] Separation of protein corona from nanoparticles under intracellular acidic conditions: effect of protonation on nanoparticle-protein and protein-protein interactions
  • 일반논문[20230308] Differences in protein distribution, conformation, and dynamics in hard and soft coronas: dependence on protein and particle electrostatics
  • 일반논문[20220721] Effects of Lipid Shape and Interactions on the Conformation, Dynamics, and Curvature of Ultrasound-Responsive Liposomes
  • 일반논문[20220324] Mechanistic Pathway of Lipid Phase-Dependent Lipid Corona Formation on Phenylalanine-Functionalized Gold Nanoparticles: A Combined Experimental and Molecular Dynamics Simulation Study
  • 일반논문[20211101] A simple strategy for signal enhancement in lateral flow assays using superabsorbent polymers
  • 일반논문[20210915] Transition-Metal Dichalcogenide Artificial Antibodies with Multivalent Polymeric Recognition Phases for Rapid Detection and Inactivation of Pathogens
  • 일반논문[20210603] Multivalent Nanosheet Antibody Mimics for Selective Microbial Recognition and Inactivation
  • 일반논문[20210501] All-Atom Simulations and Free-Energy Calculations of Antibodies Bound to the Spike Protein of SARS-CoV-2: The Binding Strength and Multivalent Hydrogen-Bond Interactions
  • 일반논문[20210429] Molecular Modeling of Protein Corona Formation and Its Interactions with Nanoparticles and Cell Membranes for Nanomedicine Applications
  • 일반논문[20210427] Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling
  • 일반논문[20210330] Effect of Protein Corona on Nanoparticle-Lipid Membrane Binding: The Binding Strength and Dynamics
  • 일반논문[20210101] Topological analysis of single-stranded DNA with an alpha-hederin nanopore
  • 일반논문[20201118] Supramolecular Functionalization for Improving Thermoelectric Properties of Single-Walled Carbon Nanotubes−Small Organic Molecule Hybrids
  • 일반논문[20200701] Heterodimer and pore formation of magainin 2 and PGLa: The anchoring and tilting of peptides in lipid bilayers
  • 일반논문[20200610] Molecular Simulations of PEGylated Biomolecules, Liposomes, and Nanoparticles for Drug Delivery Applications
  • 일반논문[20200312] Effects of Nanoparticle Electrostatics and Protein–Protein Interactions on Corona Formation: Conformation and Hydrodynamics
  • 일반논문[20200221] Supramolecular Protein Assembly Retains Its Structural Integrity at Liquid-Liquid Interface
  • 일반논문[20200219] Quantitative Interpretation of Hydration Dynamics Enabled the Fabrication of a Zwitterionic Antifouling Surface
  • 일반논문[20190328] Self-assembled DNA hollow spheres from microsponges
  • 일반논문[20190301] Effects of hydrophobic and hydrogen-bond interactions on the binding affinity of antifreeze proteins to specific ice planes
  • 일반논문[20190226] Alpha-Hederin Nanopore for Single Nucleotide Discrimination
  • 일반논문[20180912] Disassembly and trimer formation of E2 protein cage: the effects of C-terminus, salt, and protonation state
  • 일반논문[20180607] Structures, dynamics, and hydrogen-bond interactions of antifreeze proteins in TIP4P/Ice water and their dependence on force fields
  • 일반논문[20180425] Effect of low levels of lipid oxidation on the curvature, dynamics, and permeability of lipid bilayers and their interactions with cationic nanoparticles
  • 일반논문[20171101] Modulation of the Vault Protein-Protein Interaction for Tuning of Molecular Release
  • 일반논문[20170828] Effect of lipid shape on toroidal pore formation and peptide orientation in lipid bilayers
  • 일반논문[20170825] In vitro blood cell viability profiling of polymers used in molecular assembly
  • 일반논문[20170801] Adsorption of plasma proteins onto PEGylated single-walled carbon nanotubes: The effects of protein shape, PEG size and grafting density
  • 일반논문[20170719] Multilayer Nanofilms via Inkjet Printing for Stabilizing Growth Factor and Designing Desired Cell Developments
  • 일반논문[20170607] Effects of the asphaltene structure and the tetralin/heptane solvent ratio on the size and shape of asphaltene aggregates
  • 일반논문[20170401] Beneficial roles of H-donors as diluent and H-shuttle for asphaltenes in catalytic upgrading of vacuum residue
  • 일반논문[20170314] Aggregation and insertion of melittin and its analogue MelP5 into lipid bilayers at different concentrations: effects on pore size, bilayer thickness and dynamics
  • 일반논문[20170301] Cytoprotective Self-assembled RGD Peptide Nanofilms for Surface Modification of Viable Mesenchymal Stem Cells
  • 일반논문[20161101] Effect of polyelectrolyte size on multilayer conformation and dynamics at different temperatures and salt concentrations
  • 일반논문[20160509] Adsorption of Plasma Proteins onto PEGylated Lipid Bilayers: The Effect of PEG Size and Grafting Density
  • 일반논문[20160307] Effects of temperature, salt concentration, and the protonation state on the dynamics and hydrogen-bond interactions of polyelectrolyte multilayers on lipid membranes
  • 일반논문[20160301] All-atom simulations and free energy calculations of coiled-coil peptides with lipid bilayers: binding strength, structural transition, and effect on lipid dynamics
  • 일반논문[20150901] Dispersion and bilayer interaction of single-walled carbon nanotubes modulated by covalent and noncovalent PEGylation
  • 일반논문[20150901] Effects of imidazolium-based ionic liquids on the stability and dynamics of gramicidin A and lipid bilayers at different saltconcentrations
  • 일반논문[20150720] Investigation of Ion Channel Activities of Gramicidin A in the Presence of Ionic Liquids Using Model Cell Membranes
  • 일반논문[20150701] Effects of imidazolium-based ionic surfactants on the size and dynamics of phosphatidylcholine bilayers with saturated and unsaturated chains
  • 일반논문[20150601] Structural effects of tachyplesin I and its linear derivative on their aggregation and mobility in lipid bilayers
  • 일반논문[20150401] Design of a reversible inversed pH-responsive caged protein
  • 일반논문[20150228] The binding and insertion of imidazolium-based ionic surfactants into lipid bilayers: the effects of the surfactant size and salt concentration
  • 일반논문[20150101] Synergistic effects of magainin 2 and PGLa on their heterodimer formation, aggregation, and insertion into the bilayer
  • 일반논문[20140729] Molecular Dynamics Studies of PEGylated alpha-helical Coiled Coils and Their Self-Assembled Micelles
  • 일반논문[20140728] Formulation Optimization and In Vivo Proof-of-Concept Study of Thermosensitive Liposomes Balanced by Phospholipid, Elastin-Like Polypeptide, and Cholesterol
  • 일반논문[20140312] Molecular Modeling of PEGylated Peptides, Dendrimers, and Single-Walled Carbon Nanotubes for Biomedical Applications
  • 일반논문[20140228] Dynamics and stability of lipid bilayers modulated by thermosensitive polypeptides, cholesterols, and PEGylated lipids
  • 일반논문[20140121] Effect of the structural difference between Bax-a5 and Bcl-xL-a5 on their interactions with lipid bilayers
  • 일반논문[20131212] Molecular Dynamics Studies of PEGylated Single-Walled Carbon Nanotubes: The Effect of PEG Size and Grafting Density
  • 일반논문[20131119] The effects of PEGylation on the binding interaction of magainin 2 and tachyplesin I with lipid bilayer surface
  • 일반논문[20131014] Membrane penetration and curvature induced by single-walled carbon nanotubes: the effect of diameter, length, and concentration
  • 일반논문[20131014] Effect of peptide conformation on TiO2 biomineralization
  • 일반논문[20130613] Effect of Arginine Rich Peptide Length on the Structure and Binding Strength of siRNA Peptide Complexes
  • 일반논문[20130207] Interparticle Dispersion, Membrane Curvature, and Penetration Induced by Single-Walled Carbon Nanotubes Wrapped with Lipids and PEGylated Lipids
  • 일반논문[20120911] Effects of the Size, Shape, and Structural Transition of Thermosensitive Polypeptides on the Stability of Lipid Bilayers and Liposomes
  • 일반논문[20120601] Effects of salt on the size and internal structure of PAMAM dendrimers at different pH
  • 일반논문[20120601] Self-assembly of mixtures of a dendrimer and lipids: effects of hydrophobicity and electrostatics
  • 일반논문[20120426] Self-Assembly of Lipids and Single-Walled Carbon Nanotubes: Effects of Lipid Structure and PEGylation
  • 일반논문[20120312] Isolating a trimer intermediate in the self-assembly of E2 protein cage
  • 일반논문[20111108] Molecular Dynamics Studies of the Size and Internal Structure of the PAMAM Dendrimer Grafted with Arginine and Histidine
  • 일반논문[20110623] Coarse-Grained Model for PEGylated Lipids: Effect of PEGylation on the Size and Shape of Self-Assembled Structures
  • 일반논문[20110412] Effects of PEGylation on the Size and Internal Structure of Dendrimers: Self-Penetration of Long PEG Chains into the Dendrimer Core
  • 일반논문[20110407] Membrane Pore Formation Induced by Acetylated and Polyethylene Glycol-Conjugated Polyamidoamine Dendrimers
  • 학술발표[20150409] Simulations of ionic liquids, PEGylated nanotubes and antimicrobial peptides in membranes
  • 학술발표[20150210] Coarse-grained MD simulations of PEGylated coiled coils and their self-assembled micelles
  • 학술발표[20150106] MOLECULAR MODELING OF BIOLOGICAL SYSTEMS FOR NANOMEDICINE APPLICATIONS
  • 학술발표[20141023] 분자모델링을 통한 카본나노튜브, 리포솜, 폴리머, 지질막의 상호작용 연구
  • 학술발표[20140812] Molecular modeling of dendrimers and single-walled carbon nanotubes for energy applications
  • 학술발표[20140701] Molecular modeling of single-walled carbon nanotubes and their interactions with lipids, PEGs, and bilayers
  • 학술발표[20140216] MOLECULAR DYNAMICS STUDIES OF PEGYLATED ANTIMICRO BIAL PEPTIDES WITH LIPID BILAYERS.
  • 학술발표[20140115] Modeling of Polypeptide- and Polymer-Conjugated Nanoparticles for Drug Delivery Application
  • 학술발표[20131101] Self-assembly of PEGylated lipids and dendrimers
  • 학술발표[20131010] Molecular simulations of dendrimers, liposomes, and nanotubes grafted with polymers
  • 학술발표[20130722] Molecular modeling of PAMAM dendrimers modified with peptides and polymers
  • 학술발표[20130503] 고분자 결합된 덴드리머, 나노튜브의 모양 및 구조 분석을 위한 분자모델링
  • 학술발표[20130426] Molecular modeling of dendrimers, liposomes, and nanotubes grafted with polymers
  • 학술발표[20130213] Coarse-grained molecular dynamics simulations of PEGylated lipids and dendrimers
  • 학술발표[20120510] 분자모델링 기법을 통하여, 고분자 결합이 약물전달체의 구조, 물성 및 지질막 상호작용에 미치는 영향 연구
  • 학술발표[20120426] Multiscale simulations of nanoparticles, polymers, and membranes for drug delivery and nanopore applications
  • 학술발표[20120229] Molecular dynamics studies of the size and internal structure of dendrimers grafted with peptides and PEG
  • 학술발표[20110520] Coarse-grained molecular dynamics simulations of PEGylated dendrimers: the size and internal structure of dendrimers, and membrane pore formation
  • 학술발표[20110407] The effects of PEGylation on the size and internal structure of dendrimers, and membrane pore formation
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