최민구 사진

최민구 | 약학대학 약학과

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소개

본인은 서울대학교 약학대학에서 생물약제학(biopharmaceutics)를 전공하여 “항암제의 주사제 preformulation 연구”로 석사학위를, “유기양이온의 간-담즙 배설 기전에 관한 연구”로 박사학위를 취득하였다. 미국 MD Anderson Cancer Center에서 박사 후 연구원으로 재직하며 “시스플라틴의 내성 기전에 관한 연구”를 수행하였다. 약물의 흡수, 분포, 대사, 배설의 과정에 관여하는 약물측, 생체측, 제제측 인자를 통합적으로 고찰하고 규명하는 생물약제학적 연구를 통한 약물의 체내동태 개선 및 제제의 개발에 관련된 연구를 수행해오고 있으며, 주된 연구 분야는 약물의 체내동태에 영향을 주는 약물 수송체(drug transporter) 연구와 암조직 타게팅을 위한 약물전달체(drug delivery system) 개발이다

학력

  • [1997] 학사 서울대학교 제약학과
  • [1999] 석사 서울대학교 약학과
  • [2005] 박사 서울대학교 제약학과(약제학)

주요연구분야

난용성 물질의 가용화 연구
생체이용률 향상 제형 연구
약물의 체내동태 규명 및 기전 연구
약물상호작용 규명 및 기전 연구

컨설팅 가능 분야

약물 체내동태 규명
의약품 제제 설계 (preformulation)
신약후보물질의 전임상 연구

연구업적

  • 일반논문[20200302] Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings
  • 일반논문[20191101] N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice
  • 일반논문[20191031] Interactions of ginseng with therapeutic drugs
  • 일반논문[20190901] Development of sensitive analytical method of rhodanthpyrone a by a lc-ms/ms and its application to bioavailability study in rats
  • 일반논문[20190701] Detection of 13 Ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rh2, F1, Compound K, 20(S)-Protopanaxadiol, and 20(S)-Protopanaxatriol) in Human Plasma and Application of the Analytical Method to Human Pharmacokinetic Studies Following Two Week-Repeated Administration of Red Ginseng Extract
  • 일반논문[20190510] Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract
  • 일반논문[20190418] Enhanced Intestinal Permeability and Plasma Concentration of Metformin in Rats by the Repeated Administration of Red Ginseng Extract
  • 일반논문[20190331] Development and validation of an LC-MS/MS method for determination of damaurone d in rat plasma and its application to pharmacokinetic study in rats
  • 일반논문[20190222] Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
  • 일반논문[20181112] Effects of Red Ginseng Extract on the Pharmacokinetics and Elimination of Methotrexate via Mrp2 Regulation
  • 일반논문[20180831] A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng
  • 일반논문[20180801] Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine
  • 일반논문[20180701] Effect of Red Ginseng Extract on the Pharmacokinetics and Efficacy of Metformin in Streptozotocin-Induced Diabetic Rats
  • 일반논문[20180601] Characterization of Preclinical in Vitro and in Vivo Pharmacokinetic Properties of KPLA-012, a Benzopyranyl 1,2,3-Triazole Compound, with Anti-Angiogenetic and Anti-Tumor Progressive Effects
  • 일반논문[20180401] Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression
  • 일반논문[20180401] Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease
  • 일반논문[20171101] Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
  • 일반논문[20171001] Involvement of intestinal efflux and metabolic instability in the pharmacokinetics of platycodin D in rats
  • 일반논문[20170901] Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats
  • 일반논문[20170601] Comparison of gastrointestinal permeability of caffeine, propranolol, atenolol, ofloxacin, and quinidine measured using ussing chamber system and Caco-2 cell monolayer
  • 일반논문[20161201] Differential Cytotoxic Effects of Jaspine B in Various Cancer Cells
  • 일반논문[20161001] Characterization, in Vivo and in Vitro Evaluation of Solid Dispersion of Curcumin Containing d-α-Tocopheryl Polyethylene Glycol 1000 Succinate and Mannitol
  • 일반논문[20160901] Preparation and characterization of quercetin-loaded solid dispersion by solvent evaporation and freeze-drying method
  • 일반논문[20160301] Blockade of P-Glycoprotein Decreased the Disposition of Phenformin and Increased Plasma Lactate Level
  • 일반논문[20160101] Formulation and in vivo evaluation of probiotics-encapsulated pelletswith hydroxypropyl methylcellulose acetate succinate (HPMCAS)
  • 일반논문[20151201] Enhanced oral bioavailability of naringenin administered in a mixed micelle formulation with Pluronic F127 and Tween 80 in rats
  • 일반논문[20151101] Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats
  • 일반논문[20151001] Validation and application of a simple reverse phase HPLC method for in vitro dissolution studies of memantine hydrochloride tablet
  • 일반논문[20150501] Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes
  • 일반논문[20150501] Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin
  • 일반논문[20150201] Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with Pluronic F127 and Tween80 in Rats
  • 일반논문[20140523] Glycoengineering of Interferon-b 1a Improves Its Biophysical and Pharmacokinetic Properties
  • 일반논문[20140401] Transport characteristics and transporter-based drug-drug interactions of TM-25659, a novel TAZ modulator
  • 일반논문[20130401] Transport of organic cationic drugs: Effect of ion-pair formation with bile salts on the biliary excretion and pharmacokinetics
  • 일반논문[20120801] Characterization of efflux transport of the PDE5 inhibitors, vardenafil and sildenafil
  • 일반논문[20120701] Effect of CYP2C19 Genetic Polymorphism on Pharmacokinetics and Pharmacodynamics of a New Proton Pump Inhibitor, Ilaprazole
  • 일반논문[20120530] Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38
  • 일반논문[20120501] Variability of gemcitabine accumulation and its relationship to expression of nucleoside transporters in peripheral blood mononuclear cells
  • 일반논문[20120401] genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake
  • 일반논문[20120117] Effect of fatty acids on the transdermal delivery of donepezil: In vitro and in vivo evaluation
  • 일반논문[20110401] Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions
  • 일반논문[20110301] Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol
  • 일반논문[20110301] Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by the air-liquid interface method for nasal drug transport study
  • 일반논문[20110101] Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
  • 일반논문[20101201] Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters
  • 일반논문[201005] Increased Affinity to Canalicular P-gp via Formation of Lipophilic Ion-Pair Complexes with Endogenous Bile Salts is Associated with Mw Threshold in Hepatobiliary Excretion of Quaternary Ammonium Compounds
  • 일반논문[201004] Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride
  • 일반논문[200910] Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp
  • 일반논문[200907] Synergic enhancing-effect of DEET and dodecylamine on the skin permeation of testosterone from a matrix-type transdermal delivery system
  • 일반논문[200903] Reduced Antidiabetic Effect of Metformin and Down-regulation of Hepatic Oct1 in Rats with Ethynylestradiol-Induced Cholestasis
  • 일반논문[200902] Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human
  • 일반논문[200902] Testosterone-Independent Down-Regulation of Oct2 in the Kidney Medulla from a Uranyl Nitrate-induced Rat Model of Acute Renal Failure: Effects on Distribution of a Model Organic Cation, Tetraethylammonium
  • 일반논문[2009] Docetaxel microemulsion for enhanced oral bioavailability: Preparation and in vitro and in vivo evaluation
  • 일반논문[2009] Development of a sustained-release recombinant human growth hormone formulation
  • 일반논문[2009] Determination of Belotecan in the Plasma, Bile, and Urine of Rats by High-Performance Liquid Chromatography with Fluorescence Detection and Its Application to a Pharmacokinetic Study
  • 일반논문[2009] Preparation, characterization and in vitro intestinal absorption of a dry emulsion formulation containing atorvastatin calcium
  • 저서/역서[20130215] 약제학 실습
  • 지식재산권[20110215] 유비데카레논-함유 고체분산체의 제조방법 (Process for preparing ubidecarenone-containing solid dispersion)
  • 학술발표[20131122] Preparation, characterization and in vivo evaluation of curcumin-loaded solid dispersion with TPGS
  • 학술발표[20121130] expression of ENT1 and CNT1 in human liver and their condition to the hepatic uptake of ribavirin
  • 학술발표[20121024] inhibitory effect of pitavastatin and rosuvastatin on OATP1B1 and OATP1B3-mediated valsartan uptake: considerations on drug-drug interactions
  • 학술발표[20110422] Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters
  • 학술발표[20110422] Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: Considerations on drug-drug interactions
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