최민구 사진

최민구 | 약학대학 약학과

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소개

본인은 서울대학교 약학대학에서 생물약제학(biopharmaceutics)를 전공하여 “항암제의 주사제 preformulation 연구”로 석사학위를, “유기양이온의 간-담즙 배설 기전에 관한 연구”로 박사학위를 취득하였다. 미국 MD Anderson Cancer Center에서 박사 후 연구원으로 재직하며 “시스플라틴의 내성 기전에 관한 연구”를 수행하였다. 약물의 흡수, 분포, 대사, 배설의 과정에 관여하는 약물측, 생체측, 제제측 인자를 통합적으로 고찰하고 규명하는 생물약제학적 연구를 통한 약물의 체내동태 개선 및 제제의 개발에 관련된 연구를 수행해오고 있으며, 주된 연구 분야는 약물의 체내동태에 영향을 주는 약물 수송체(drug transporter) 연구와 암조직 타게팅을 위한 약물전달체(drug delivery system) 개발이다

학력

  • [1997] 학사 서울대학교 제약학과
  • [1999] 석사 서울대학교 약학과
  • [2005] 박사 서울대학교 제약학과(약제학)

주요연구분야

난용성 물질의 가용화
생물약제학
암조직 타게팅을 위한 약물 전달체
약물 수송체

컨설팅 가능 분야

약물의 흡수, 분포, 대사, 배설과 이에 따른 체내동태 변화
약물 전달체 (drug delivery system) 개발
의약품 제형의 preformulation

연구업적

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  • 일반논문[20190418] Enhanced Intestinal Permeability and Plasma Concentration of Metformin in Rats by the Repeated Administration of Red Ginseng Extract
  • 일반논문[20190331] Development and validation of an LC-MS/MS method for determination of damaurone d in rat plasma and its application to pharmacokinetic study in rats
  • 일반논문[20190222] Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
  • 일반논문[20181112] Effects of Red Ginseng Extract on the Pharmacokinetics and Elimination of Methotrexate via Mrp2 Regulation
  • 일반논문[20180831] A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng
  • 일반논문[20180801] Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine
  • 일반논문[20180701] Effect of Red Ginseng Extract on the Pharmacokinetics and Efficacy of Metformin in Streptozotocin-Induced Diabetic Rats
  • 일반논문[20180601] Characterization of Preclinical in Vitro and in Vivo Pharmacokinetic Properties of KPLA-012, a Benzopyranyl 1,2,3-Triazole Compound, with Anti-Angiogenetic and Anti-Tumor Progressive Effects
  • 일반논문[20180401] Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression
  • 일반논문[20180401] Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease
  • 일반논문[20171101] Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
  • 일반논문[20171001] Involvement of intestinal efflux and metabolic instability in the pharmacokinetics of platycodin D in rats
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  • 일반논문[20161201] Differential Cytotoxic Effects of Jaspine B in Various Cancer Cells
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  • 일반논문[20160101] Formulation and in vivo evaluation of probiotics-encapsulated pelletswith hydroxypropyl methylcellulose acetate succinate (HPMCAS)
  • 일반논문[20151201] Enhanced oral bioavailability of naringenin administered in a mixed micelle formulation with Pluronic F127 and Tween 80 in rats
  • 일반논문[20151101] Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats
  • 일반논문[20151001] Validation and application of a simple reverse phase HPLC method for in vitro dissolution studies of memantine hydrochloride tablet
  • 일반논문[20150501] Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes
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  • 일반논문[20150201] Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with Pluronic F127 and Tween80 in Rats
  • 일반논문[20140523] Glycoengineering of Interferon-b 1a Improves Its Biophysical and Pharmacokinetic Properties
  • 일반논문[20140401] Transport characteristics and transporter-based drug-drug interactions of TM-25659, a novel TAZ modulator
  • 일반논문[20130401] Transport of organic cationic drugs: Effect of ion-pair formation with bile salts on the biliary excretion and pharmacokinetics
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  • 일반논문[20120530] Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38
  • 일반논문[20120501] Variability of gemcitabine accumulation and its relationship to expression of nucleoside transporters in peripheral blood mononuclear cells
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  • 일반논문[20110301] Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol
  • 일반논문[20110301] Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by the air-liquid interface method for nasal drug transport study
  • 일반논문[20110101] Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
  • 일반논문[20101201] Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters
  • 일반논문[201005] Increased Affinity to Canalicular P-gp via Formation of Lipophilic Ion-Pair Complexes with Endogenous Bile Salts is Associated with Mw Threshold in Hepatobiliary Excretion of Quaternary Ammonium Compounds
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  • 일반논문[200910] Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp
  • 일반논문[200907] Synergic enhancing-effect of DEET and dodecylamine on the skin permeation of testosterone from a matrix-type transdermal delivery system
  • 일반논문[200903] Reduced Antidiabetic Effect of Metformin and Down-regulation of Hepatic Oct1 in Rats with Ethynylestradiol-Induced Cholestasis
  • 일반논문[200902] Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human
  • 일반논문[200902] Testosterone-Independent Down-Regulation of Oct2 in the Kidney Medulla from a Uranyl Nitrate-induced Rat Model of Acute Renal Failure: Effects on Distribution of a Model Organic Cation, Tetraethylammonium
  • 일반논문[2009] Docetaxel microemulsion for enhanced oral bioavailability: Preparation and in vitro and in vivo evaluation
  • 일반논문[2009] Development of a sustained-release recombinant human growth hormone formulation
  • 일반논문[2009] Determination of Belotecan in the Plasma, Bile, and Urine of Rats by High-Performance Liquid Chromatography with Fluorescence Detection and Its Application to a Pharmacokinetic Study
  • 일반논문[2009] Preparation, characterization and in vitro intestinal absorption of a dry emulsion formulation containing atorvastatin calcium
  • 저서/역서[20130215] 약제학 실습
  • 지식재산권[20110215] 유비데카레논-함유 고체분산체의 제조방법 (Process for preparing ubidecarenone-containing solid dispersion)
  • 학술발표[20131122] Preparation, characterization and in vivo evaluation of curcumin-loaded solid dispersion with TPGS
  • 학술발표[20121130] expression of ENT1 and CNT1 in human liver and their condition to the hepatic uptake of ribavirin
  • 학술발표[20121024] inhibitory effect of pitavastatin and rosuvastatin on OATP1B1 and OATP1B3-mediated valsartan uptake: considerations on drug-drug interactions
  • 학술발표[20110422] Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters
  • 학술발표[20110422] Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: Considerations on drug-drug interactions
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