이충현 사진

이충현 | 약학대학 약학과 (약학관)

  • 직급:
    부교수

학력

  • [2000] 학사 서울대학교 수의학과(수의학) 수의학
  • [2002] 석사 서울대학교 수의학과 신경해부학
  • [2008] 박사 서울대학교 수의학과 신경해부학

주요연구분야

노화에 따른 뇌 안에서의 변화
신경세포 손상 및 보호

연구업적

  • 일반논문[20210901] Differences in TNF‑α and TNF‑R1 expression in damaged neurons and activated astrocytes of the hippocampal CA1 region between young and adult gerbils following transient forebrain ischemia
  • 일반논문[20210801] Neuroprotective and Anti-Inflammatory Effects of Pinus densiflora Bark Extract in Gerbil Hippocampus Following Transient Forebrain Ischemia
  • 일반논문[20210701] Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in the Ischemic Neurons
  • 일반논문[20210401] Ischemia-Reperfusion under Hyperthermia Increases Heme Oxygenase-1 in Pyramidal Neurons and Astrocytes with Accelerating Neuronal Loss in Gerbil Hippocampus
  • 일반논문[20210401] Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage
  • 일반논문[20210401] Neuroprotective Effects of Salicin in a Gerbil Model of Transient Forebrain Ischemia by Attenuating Oxidative Stress and Activating PI3K/Akt/GSK3 beta Pathway
  • 일반논문[20210101] CD200 Change Is Involved in Neuronal Death in Gerbil Hippocampal CA1 Field Following Transient Forebrain Ischemia and Postischemic Treatment with Risperidone Displays Neuroprotection without CD200 Change
  • 일반논문[20210101] Neuronal Death in the CNS Autonomic Control Center Comes Very Early after Cardiac Arrest and Is Not Significantly Attenuated by Prompt Hypothermic Treatment in Rats
  • 일반논문[20201001] Long-Term Alternating Fasting Increases Interleukin-13 in the Gerbil Hippocampus, But Does Not Protect BBB and Pyramidal Neurons From Ischemia-Reperfusion Injury
  • 일반논문[20200801] Comparison of neuronal death and expression of TNF-alpha and MCT4 in the gerbil hippocampal CA1 region induced by ischemia/reperfusion under hyperthermia to those under normothermia
  • 일반논문[20200801] Age-dependent alterations in the immunoreactivity of macrophage inflammatory protein-3 alpha and its receptor CCR6 in the gerbil hippocampus
  • 일반논문[20200501] p66shc siRNA-Encapsulated PLGA Nanoparticles Ameliorate Neuropathic Pain Following Spinal Nerve Ligation
  • 일반논문[20200201] Novel functions for 2-phenylbenzimidazole-5-sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis
  • 일반논문[20200201] Change of Nurr1 expression in mouse hippocampal CA3 region following excitotoxic neuronal damage
  • 일반논문[20200101] Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia
  • 일반논문[20191101] Improved HCN channels in pyramidal neurons and their new expression levels in pericytes and astrocytes in the gerbil hippocampal CA1 subfield following transient ischemia
  • 일반논문[20191101] Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process
  • 일반논문[20191001] A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation
  • 일반논문[20191001] Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress
  • 일반논문[20190901] Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia
  • 일반논문[20190901] Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia
  • 일반논문[20190901] Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress
  • 일반논문[20190801] Stronger antioxidant enzyme immunoreactivity of Populus tomentiglandulosa extract than ascorbic acid in rat liver and kidney
  • 일반논문[20190601] Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions
  • 일반논문[20190301] Intermittent fasting increases the expressions of SODs and catalase in granule and polymorphic cells and enhances neuroblast dendrite complexity and maturation in the adult gerbil dentate gyrus
  • 일반논문[20190204] Decreased dopamine in striatum and difficult locomotor recovery from MPTP insult after exposure to radiofrequency electromagnetic fields
  • 일반논문[20181231] Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus
  • 일반논문[20181231] Chronic high-fat diet-induced obesity in gerbils increases pro-inflammatory cytokines and mTOR activation, and elicits neuronal death in the striatum following brief transient ischemia
  • 일반논문[20181130] Time-Course Changes and New Expressions of MIP-3 and Its Receptor, CCR6, in the Gerbil Hippocampal CA1 Area Following Transient Global Cerebral Ischemia
  • 일반논문[20180801] Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia
  • 일반논문[20180701] Early IV-injected human dermis-derived mesenchymal stem cells after transient global cerebral ischemia do not pass through damaged blood-brain barrier
  • 일반논문[20180701] Effect of Rufinamide on the kainic acid-induced excitotoxic neuronal death in the mouse hippocampus
  • 일반논문[20180601] Age-dependent decrease of Nurr1 protein expression in the gerbil hippocampus
  • 일반논문[20180401] Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus
  • 일반논문[20180401] Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing expressions of IGF-1, IGF-1R and p-CREB
  • 일반논문[20180301] Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus
  • 일반논문[20180301] Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage
  • 일반논문[20180301] Glehnia littoralis Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B
  • 일반논문[20180301] Age-dependent alteration in the expression of oligodendrocyte-specific protein in the gerbil hippocampus
  • 일반논문[20170901] Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils
  • 일반논문[20170701] Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus
  • 일반논문[20170601] Sac-1004, a vascular leakage blocker, reduces cerebral ischemia-reperfusion injury by suppressing blood-brain barrier disruption and inflammation
  • 일반논문[20170601] Atomoxetine Protects Against NMDA Receptor-mediated Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia
  • 일반논문[20170401] Time-Course Change of Redd1 Expressions in the Hippocampal CA1 Region Following Chronic Cerebral Hypoperfusion
  • 일반논문[20170301] Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
  • 일반논문[20170201] Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes
  • 일반논문[20161201] Hydroquinone Strongly Alleviates Focal Ischemic Brain Injury via Blockage of Blood-Brain Barrier Disruption in Rats
  • 일반논문[20161101] Pretreated duloxetine protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury through decreases of glial activation and oxidative stress
  • 일반논문[20161001] Age-dependent increase in the expression of antioxidant-like protein-1 in the gerbil hippocampus
  • 일반논문[20161001] Differential activation of c-Fos in the paraventricular nuclei of the hypothalamus and thalamus following myocardial infarction in rats
  • 일반논문[20161001] Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke
  • 일반논문[20160901] New GABAergic Neurogenesis in the Hippocampal CA1 Region of a Gerbil Model of Long-Term Survival after Transient Cerebral Ischemic Injury
  • 일반논문[20160801] Effects of Chronic Scopolamine Treatment on Cognitive Impairments and Myelin Basic Protein Expression in the Mouse Hippocampus
  • 일반논문[20160701] Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats
  • 일반논문[20160701] Ischemia-Induced Changes of PRAS40 and p-PRAS40 Immunoreactivities in the Gerbil Hippocampal CA1 Region After Transient Cerebral Ischemia
  • 일반논문[20160601] Effects of melatonin on cognitive impairment and hippocampal neuronal damage in a rat model of chronic cerebral hypoperfusion
  • 일반논문[20160601] Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus
  • 일반논문[20160301] Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging
  • 일반논문[20151201] Neuroprotection and reduced gliosis by atomoxetine pretreatment in a gerbil model of transient cerebral ischemia
  • 일반논문[20151201] Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis
  • 일반논문[20151101] The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice
  • 일반논문[20150801] Differences in the protein expression levels of Trx2 and Prx3 in the hippocampal CA1 region between adult and aged gerbils following transient global cerebral ischemia
  • 일반논문[20150601] Effect of Oenanthe Javanica Extract on Antioxidant Enzyme in the Rat Liver
  • 일반논문[20150501] Effect of pioglitazone on excitotoxic neuronal damage in the mouse hippocampus
  • 일반논문[20150301] New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia
  • 일반논문[20150301] Change of calbindin D-28k protein expression in the mice hippocampus after lipopolysaccharide treatment
  • 일반논문[20150201] Ischemic preconditioning protects hippocampal pyramidal neurons from transient ischemic injury via the attenuation of oxidative damage through upregulating heme oxygenase-1
  • 일반논문[20150101] Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia
  • 일반논문[20141201] Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia
  • 일반논문[20141001] Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I
  • 일반논문[20140915] Changes and expressions of Redd1 in neurons and glial cells in the gerbil hippocampus proper following transient global cerebral ischemia
  • 일반논문[20140901] Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord
  • 일반논문[20140801] Increased Dynamin-1 and -2 Protein Expression in the Aged Gerbil Hippocampus
  • 일반논문[20140701] Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in the Gerbil Hippocampus
  • 일반논문[20140630] Change of peroxisome proliferator-activated receptor γ expression pattern in the gerbil dentate gyrus after transient global cerebral ischemia
  • 일반논문[20140601] Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke
  • 일반논문[20140401] Decreased Insulin-Like Growth Factor-I and Its Receptor Expression in the Hippocampus and Somatosensory Cortex of the Aged Mouse
  • 일반논문[20140330] Cell proliferation and neuroblast differentiation in the dentate gyrus of high-fat diet-fed mice are increased after rosiglitazone treatment
  • 일반논문[20140215] Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia
  • 일반논문[20131201] Time-course Changes in Immunoreactivities of Glucokinase and Glucokinase Regulatory Protein in the Gerbil Hippocampus Following Transient Cerebral Ischemia
  • 일반논문[20130930] Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus
  • 일반논문[20130901] Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke
  • 일반논문[20130501] Decreased Glucokinase Protein Expression in the Aged Gerbil Hippocampus
  • 일반논문[20130201] Neuroprotective effects of Alpinia katsumadai against experimental ischemic damage via control of oxidative stress
  • 일반논문[20130101] Comparison of Alpha-Synuclein Immunoreactivity in the Hippocampus Between the Adult and Aged Beagle Dogs
  • 일반논문[20121101] Comparison of Trophic Factors Changes in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia
  • 일반논문[20121001] Comparison of Glial Activation in the Hippocampal CA1 Region Between The Young and Adult Gerbils After Transient Cerebral Ischemia
  • 일반논문[20121001] Protective Effects of a Novel Synthetic Alpha-Lipoic Acid-Decursinol Hybrid Compound in Experimentally Induced Transient Cerebral Ischemia
  • 일반논문[20120830] Effects of ADHD therapeutic agents, methylphenidate and atomoxetine, on hippocampal neurogenesis in the adolescent mouse dentate gyrus
  • 일반논문[20120715] Neuroprotective effect of fucoidin on lipopolysaccharide accelerated cerebral ischemic injury through inhibition of cytokine expression and neutrophil infiltration
  • 일반논문[20120701] Changes in Ribosomal Protein S3 Immunoreactivity and its Protein Levels in the Gerbil Hippocampus Following Subacute and Chronic Restraint Stress
  • 일반논문[20120601] Comparison of inflammatory cytokines changes in the hippocampal CA1 region between the young and adult gerbil after transient cerebral ischemia
  • 일반논문[20120501] Comparison of the Immunoreactivity of Trx2/Prx3 Redox System in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia
  • 일반논문[20120501] Changes of Ribosomal Protein S3 Immunoreactivity and Its New Expression in Microglia in the Mice Hippocampus After Lipopolysaccharide Treatment
  • 일반논문[20120401] Comparison of Neurogenesis in the Dentate Gyrus Between the Adult and Aged Gerbil Following Transient Global Cerebral Ischemia
  • 일반논문[20120301] Increased Immunoreactivities of Cleaved alpha II-Spectrin and Cleaved Caspase-3 in the Aged Dog Spinal Cord
  • 일반논문[20120301] FoxO3a Changes in Pyramidal Neurons and Expresses in Non-Pyramidal Neurons and Astrocytes in the Gerbil Hippocampal CA1 Region After Transient Cerebral Ischemia
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