알츠하이머 뇌 조직 투명화 이미징 및 행동 분석 실험실
지도교원:손혜주
구성원: 교원(교직원) 1명
홈페이지:
전화번호:041-550-3046
위치:천안캠퍼스 의학관 4층 뇌분자영상 행동실험실 454-03호실
구성원 소개
연혁
2020
- 01월 01일
- ● Dominantly Inherited Alzheimer’s Network Observational cohort study (D1934) 국제 공동 연구
- 01월 01일
- ● 동물 질환 모델에서 성상 세포 회복 탄력성에 대한 치료제의 신경보호 효과 평가 방법 및 시스템 [국제 특허 PCT 출원]
2021
- 01월 01일
- ● 알츠하이머 뇌조직 투명화 이미징 및 행동 분석 실험실 설립.
- 06월 01일
- ● 성상세포 회복탄력성에 대한 graphene oxide의 신경 보호 효과 과학기술정보 통신부 (한국연구재단)
- 10월 01일
- ● 유전자 조작 치매 생쥐의 대뇌에서 항 tie2 항체의 약동학/약력학적 분포를 규명하기 위한 [ 89 Zr]-DFO 표지 항 tie2 항체 Positron Emission Tomography 영상 및 ex vivo 연구 (파멥신)
2022
- 05월 01일
- ● 유전자 변형 치매 마우스를 이용한 lightsheet slide scanner와 라만 분자 영상 기술 비교 및 특성 연구 (한국전자통신연구원, ETRI)
연구분야
- ● Stock of genetically modified mouse models of Alzheimer’s disease and Parkinson’s disease
- ● Brain tissue clearing and 3D volume immunostaging
- ● Photon bioimaging analysis and neuropathlogy (amyloid, tau, alpha synuclein) quantification
- ● Animal PET and MRI imaging processing and quantitative analysis
- ● Behavioral analysis
- ● Evaluation of protective lifestyle on brain resileince and cognitive outcome in Alzheimer’s disease
연구내용 및 보유기술
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<교과서>
1. Atlas of Nuclear Medicine in Musculoskeletal System, Springer, 2022
<국내 학술지>
2. Kim JS, Son HJ, Oh M, Lee DY, Kim HW, Oh J. 60 Years of Achievements by KSNM in Neuroimaging Research. Nucl Med Mol Imaging. 2022 Feb;56(1):3-16.
<국외 학술지>
3. Son, HJ, Lee YM, Lee JH. "Incidental Detection of Ovarian Cancer as a Solitary Peridiaphragmatic Distant Lymph Node Metastasis without Pelvic Lesions on 18F-FDG PET/CT." Diagnostics 11.3 (2021): 422.
4. Son HJ, Oh JS, Oh M, Lee SJ, Oh SJ, Chung SJ, Kim JS. Test-retest reproducibility of dopamine transporter density measured with [18 F] FP-CIT PET in patients with essential tremor and Parkinson's disease. Annals of Nuclear Medicine (2021): 1-8.
5. Son HJ, Oh JS, Oh M, Kim SJ, Lee JH, Roh JH, Kim JS. The clinical feasibility of deep learning-based classification of amyloid PET images in visually equivocal cases. Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):332-341. (JCR 2020 IF 9.2)
6. Son HJ, Oh JS, Roh JH, Seo SW, Oh M, Lee SJ, Oh SJ, Kim JS. Differences in gray and white matter 18F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias. Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):357-366 (JCR 2020 IF 9.2)
1. Atlas of Nuclear Medicine in Musculoskeletal System, Springer, 2022
<국내 학술지>
2. Kim JS, Son HJ, Oh M, Lee DY, Kim HW, Oh J. 60 Years of Achievements by KSNM in Neuroimaging Research. Nucl Med Mol Imaging. 2022 Feb;56(1):3-16.
<국외 학술지>
3. Son, HJ, Lee YM, Lee JH. "Incidental Detection of Ovarian Cancer as a Solitary Peridiaphragmatic Distant Lymph Node Metastasis without Pelvic Lesions on 18F-FDG PET/CT." Diagnostics 11.3 (2021): 422.
4. Son HJ, Oh JS, Oh M, Lee SJ, Oh SJ, Chung SJ, Kim JS. Test-retest reproducibility of dopamine transporter density measured with [18 F] FP-CIT PET in patients with essential tremor and Parkinson's disease. Annals of Nuclear Medicine (2021): 1-8.
5. Son HJ, Oh JS, Oh M, Kim SJ, Lee JH, Roh JH, Kim JS. The clinical feasibility of deep learning-based classification of amyloid PET images in visually equivocal cases. Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):332-341. (JCR 2020 IF 9.2)
6. Son HJ, Oh JS, Roh JH, Seo SW, Oh M, Lee SJ, Oh SJ, Kim JS. Differences in gray and white matter 18F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias. Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):357-366 (JCR 2020 IF 9.2)
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7. Son HJ, Jeong YJ, Yoon HJ, Kim JW, Choi GE, Park JH, Kang DY. Parkinson disease-related cortical and striatal cognitive patterns in dual time F-18 FP CIT: evidence for neural correlates between the caudate and the frontal lobe. Q J Nucl Med Mol Imaging. 2019 Dec;63(4):379-386.
8. Son HJ, Jeong YJ, Yoon HJ, Lee SY, Choi GE, Park JA, Kim MH, Lee KC, Lee YJ, Kim MK, Cho K, Kang DY. Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer's disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben. BMC Neurosci. 2018 Jul 27;19(1):45.
9. Son HJ, Ryu JS. 99mTc-MAA total body imaging of patent right-to-left shunt with invisible brain activity. Hell J Nucl Med. 2020 May-Aug;23(2):209-210
10. Son HJ, Jeong YJ, Yoon HJ, Wang L, Kim HJ, Park JH, Kang DY. Visual Pattern and Serial Quantitation of 18F-Sodium Fluoride PET/CT in Asymptomatic Patients After Hip and Knee Arthroplasty. Nucl Med Mol Imaging. 2016 Dec;50(4):308-321.
11. Son HJ, Jeong YJ, Yoon HJ, Park JH, Kang DY. Visual and Quantitative Analysis Methods of Respiratory Patterns for Respiratory Gated PET/CT. Biomed Res Int. 2016;2016:7862539.
12. Son HJ, Jeong YJ, Jeong JS, Kang DY. An inflammatory dentigerous cyst shows rim uptake on bone scan: a case report. Nucl Med Mol Imaging. 2014 Mar;48(1):79-81.
13. Lee HJ, Son HJ, Yun M, Moon JW, Kim YN, Woo JY, Lee SH. Prone position [18F]FDG PET/CT to reduce respiratory motion artefacts in the evaluation of lung nodules. Eur Radiol. 2021 Jul;31(7):4606-4614.
8. Son HJ, Jeong YJ, Yoon HJ, Lee SY, Choi GE, Park JA, Kim MH, Lee KC, Lee YJ, Kim MK, Cho K, Kang DY. Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer's disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben. BMC Neurosci. 2018 Jul 27;19(1):45.
9. Son HJ, Ryu JS. 99mTc-MAA total body imaging of patent right-to-left shunt with invisible brain activity. Hell J Nucl Med. 2020 May-Aug;23(2):209-210
10. Son HJ, Jeong YJ, Yoon HJ, Wang L, Kim HJ, Park JH, Kang DY. Visual Pattern and Serial Quantitation of 18F-Sodium Fluoride PET/CT in Asymptomatic Patients After Hip and Knee Arthroplasty. Nucl Med Mol Imaging. 2016 Dec;50(4):308-321.
11. Son HJ, Jeong YJ, Yoon HJ, Park JH, Kang DY. Visual and Quantitative Analysis Methods of Respiratory Patterns for Respiratory Gated PET/CT. Biomed Res Int. 2016;2016:7862539.
12. Son HJ, Jeong YJ, Jeong JS, Kang DY. An inflammatory dentigerous cyst shows rim uptake on bone scan: a case report. Nucl Med Mol Imaging. 2014 Mar;48(1):79-81.
13. Lee HJ, Son HJ, Yun M, Moon JW, Kim YN, Woo JY, Lee SH. Prone position [18F]FDG PET/CT to reduce respiratory motion artefacts in the evaluation of lung nodules. Eur Radiol. 2021 Jul;31(7):4606-4614.
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14. Song, Y. H., Moon, J. W., Kim, Y. N., Woo, J. Y., Son, H. J., Lee, S. H., & Hwang, H. S. (2022). Tissue Fraction Correction and Visual Analysis Increase Diagnostic Sensitivity in Predicting Malignancy of Ground-Glass Nodules on [18F]FDG PET/CT: A Bicenter Retrospective Study. Diagnostics (Basel, Switzerland), 12(5), 1292.
15. Kim C, Lee JS, Han Y, Chae SY, Jin S, Sung C, Son HJ, Oh SJ, Lee SJ, Oh JS, Cho YP, Kwon TW, Lee DH, Jang S, Kim B, Koglin N, Berndt M, Stephens AW, Moon DH. Glycoprotein IIb/IIIa receptor imaging with 18F-GP1 positron emission tomography for acute venous thromboembolism: an open-label, non-randomized, first-in-human phase 1 study. J Nucl Med. 2018 Jun 29;60(2):244–9.
16. Chae SY, Son HJ, Lee DY, Shin E, Oh JS, Seo SY, Baek S, Kim JY, Na SJ, Moon DH. Comparison of diagnostic sensitivity of [18F]fluoroestradiol and [18F]fluorodeoxyglucose positron emission tomography/computed tomography for breast cancer recurrence in patients with a history of estrogen receptor-positive primary breast cancer. EJNMMI Res. 2020 May 24;10(1):54.
17. Jeong YJ, Kang DY, Yoon HJ, Son HJ. Additional value of F-18 FDG PET/CT for initial staging in breast cancer with clinically negative axillary nodes. Breast Cancer Res Treat. 2014 May;145(1):137-42.
18. Shin E, Sung C, Son HJ, Lee DY, Chae SY, Moon DH. Value of the Filtration Fraction Assessed by Dynamic 99mTc-Diethylenetriaminepentaacetic Acid Renal Scintigraphy After Angiotensin-Converting Enzyme Inhibition for the Diagnosis of Renovascular Hypertension. Nucl Med Mol Imaging. 2019 Aug;53(4):270-277.
16. Oh M, Lee N, Kim C, Son HJ, Sung C, Oh SJ, Lee SJ, Chung SJ, Lee CS, Kim JS. Diagnostic accuracy of dual-phase 18F-FP-CIT PET imaging for detection and differential diagnosis of Parkinsonism. Sci Rep. 2021 Jul 22;11(1):14992.
15. Kim C, Lee JS, Han Y, Chae SY, Jin S, Sung C, Son HJ, Oh SJ, Lee SJ, Oh JS, Cho YP, Kwon TW, Lee DH, Jang S, Kim B, Koglin N, Berndt M, Stephens AW, Moon DH. Glycoprotein IIb/IIIa receptor imaging with 18F-GP1 positron emission tomography for acute venous thromboembolism: an open-label, non-randomized, first-in-human phase 1 study. J Nucl Med. 2018 Jun 29;60(2):244–9.
16. Chae SY, Son HJ, Lee DY, Shin E, Oh JS, Seo SY, Baek S, Kim JY, Na SJ, Moon DH. Comparison of diagnostic sensitivity of [18F]fluoroestradiol and [18F]fluorodeoxyglucose positron emission tomography/computed tomography for breast cancer recurrence in patients with a history of estrogen receptor-positive primary breast cancer. EJNMMI Res. 2020 May 24;10(1):54.
17. Jeong YJ, Kang DY, Yoon HJ, Son HJ. Additional value of F-18 FDG PET/CT for initial staging in breast cancer with clinically negative axillary nodes. Breast Cancer Res Treat. 2014 May;145(1):137-42.
18. Shin E, Sung C, Son HJ, Lee DY, Chae SY, Moon DH. Value of the Filtration Fraction Assessed by Dynamic 99mTc-Diethylenetriaminepentaacetic Acid Renal Scintigraphy After Angiotensin-Converting Enzyme Inhibition for the Diagnosis of Renovascular Hypertension. Nucl Med Mol Imaging. 2019 Aug;53(4):270-277.
16. Oh M, Lee N, Kim C, Son HJ, Sung C, Oh SJ, Lee SJ, Chung SJ, Lee CS, Kim JS. Diagnostic accuracy of dual-phase 18F-FP-CIT PET imaging for detection and differential diagnosis of Parkinsonism. Sci Rep. 2021 Jul 22;11(1):14992.
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<특허 목록>
1) 알츠하이머 동물 질환 모델에서 성상 세포 회복 탄력성에 대한 치료제의 신경보호 효과 평가 방법 및 시스템 [국제 특허 출원번호 PCT/KR2022/01316]
2) 뇌질환 동물 모델에서 방사성 동위원소를 이용하여 물질의 약동학/약력학적 분포를 평가하는 방법 및 시스템 [출원번호10-2021-0137690]
2) 동물 질환 모델에서 치료제 약효 평가 방법 및 시스템 [출원번호 10-2021-0116902]
1) 알츠하이머 동물 질환 모델에서 성상 세포 회복 탄력성에 대한 치료제의 신경보호 효과 평가 방법 및 시스템 [국제 특허 출원번호 PCT/KR2022/01316]
2) 뇌질환 동물 모델에서 방사성 동위원소를 이용하여 물질의 약동학/약력학적 분포를 평가하는 방법 및 시스템 [출원번호10-2021-0137690]
2) 동물 질환 모델에서 치료제 약효 평가 방법 및 시스템 [출원번호 10-2021-0116902]