임상생화학 연구실
지도교원:김지연
구성원: 교원(교직원) 1명
홈페이지:바로가기
전화번호:041-550-1454
위치:천안캠퍼스 보건과학관 1층 임상생화학실험실(김지연) 116-04호실
구성원 소개
연혁
2014
- 03월 01일
- 을지대학교 의과대학 임상병리학과 면역화학연구실 운영 (석사 3명, 박사 1명 졸업)
2019
- 09월 01일
- 단국대학교 공공보건과학대학 임상병리학과 임상생화학연구실 운영 (석사 1명 졸업)
연구분야
- Peptide based drug development
- Lung cancer metastasis & epithelial-to-mesenchymal transition
- Drug repositioning
연구내용 및 보유기술
<고리형 RGD 기반 펩타이드를 활용한 비소세포성폐암의 상피중배엽전이 억제 기전 연구>
1. Cyclic pentapeptide cRGDfK enhances the inhibitory effect of sunitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells (Plos One, 2020)
2. Cyclic RGD Pentapeptide Cilengitide Enhances Efficacy of Gefitinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Invasion in Human Non-Small Cell Lung Cancer Cells (Frontiers in Pharmacology, 2021)
2. Cyclic RGD Pentapeptide Cilengitide Enhances Efficacy of Gefitinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Invasion in Human Non-Small Cell Lung Cancer Cells (Frontiers in Pharmacology, 2021)
<비타민 C-유도 펩타이드 유도체를 활용한 BMP-유도 골세포 분화 및 콜라겐 합성 촉진 기전 연구>
1. Synthesis and biological evaluation of the anti-melaogenesis effect of coumaric and caffeic acid-conjugated peptides in human melanocytes (Frontiers in Pharmacology, 2020)
2. Synthesis and biological evaluation of Ascorbiy-conjugated peptide derivatives as collagen synthesis stimulating agents in human skin fibroblasts (International Journal of Peptide Research and Therapeutics, 2020)
2. Synthesis and biological evaluation of Ascorbiy-conjugated peptide derivatives as collagen synthesis stimulating agents in human skin fibroblasts (International Journal of Peptide Research and Therapeutics, 2020)
<신약재창출 (Drug repositining) 기술을 활용한 폐암치료제의 발굴 및 병용투여효과 기전 연구>
1. Combination effect of cilengitide derivatives with gefitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells (Bulletin of the Korean Chemical Society, 2022)
2. Combination effect of cilengitide with erlotinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells (International Journal of Molecular Science, 2022)
2. Combination effect of cilengitide with erlotinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells (International Journal of Molecular Science, 2022)