인체위해성평가연구소(CHRA)

인체 위해성 평가

• 위해평가(Risk assessment)란 인체가 외부 위해요소에 노출되었을때 발생할 수 있는 유해 영향과 발생확률을 과학적으로 예측하는 일련의 과정이다.
• 화학물질의 인체 및 동물에 대한 독성 자료를 기반으로 인체에 미치는 영향을 평가하여 화장품 및 원료 물질에 대한 안전성 평가자료로 활용한다.

서비스 절차

• 담당자와 면담 (전화) 후 위해평가 의뢰


• 위해평가 진행(약4주)



    - 위험성 확인(Hazard identification)

          : 위해요소에 노출됨에 따라 발생할 수 있는 독성의 정도와 영향의 종류등을 파악하는 과정

    - 위험성 결정(Hazard characterization)

          : 동물실험 결과, 동물대체 실험결과 등의 불확실성등을 보정하여 인체노출 허용량을 결정하는 과정

    - 노출평가(Exposure assessment)

          : 제품의 사용을 통하여 노출되는 위해요소의 양 또는 수준을 정량적 또는 정성적으로 산출하는 과정

    - 위해도 결정(Risk characterization)

          : 위해요소 및 이를 함유한 제품의 사용에 따른 건강상 영향, 인체노출 허용량 또는 수준 및 제품 이외의 환경등에 의하여 노출되는


            위해요소의 양을 고려하여 사람에게 미칠수 있는 위해의 정도와 발생 빈도 등을 예측하는 정량적 또는 정성적 과정



• 위해평가 결과 보고서 작성 (약 1주)

관련논문

• Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats. Toxics 11: 337. 2023.

• Negligible Toxicokinetic Differences of Glyphosate by Different Vehicles in Rats. Toxics 11: 67. 2023.

• Urinary Metabolomics in Young Soccer Players after Winter Training Season. Metabolites 12: 1283. 2022.

• Current trends in read-across applications for chemical risk assessments and chemical registrations in the Republic of Korea. Journal of Toxicology and Environmental Health, Part B-Critical Reviews 25: 393-404. 2022.

• A Metabolomics Approach to Sulforaphane Efficacy in Secondhand Smoking-Induced Pulmonary Damage in Mice. Metabolites 12: 518. 2022.

• Prenatal developmental toxicity study of 2,4-dichlorobenzyl alcohol in rats. Regulatory Toxicology and Pharmacology 132:105168. 2022.

• Microfluidic system with light intensity filters facilitating the application of photodynamic therapy for high-throughput drug screening. Photodiagnosis and Photodynamic Therapy 38:1028123. 2022.

• Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model. Journal of Toxicology and Environmental Health, part A 85:1-13. 2022.

• Using intracellular metabolic profiling to identify novel biomarkers of cisplatin-induced acute kidney injury in NRK-52E cells. Journal of Toxicology and Environmental Health, part A 85:29-42. 2022.

• Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis. Journal of Toxicology and Environmental Health, part A 84:1004-1019. 2021.

• Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells. Journal of Toxicology and Environmental Health, part A 84:922-931. 2021.

• Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence . Journal of Toxicology and Environmental Health, part A 84:846-857. 2021.

• Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats. Archives of Toxicology 95:2037-2050. 2021.

• Current opinion on risk assessment of cosmetics. Journal of Toxicology and Environmental Health, part B 24:137-161. 2021.

• Metabolomics approach to biomarkers of dry eye disease using 1H-NMR in rats. Journal of Toxicology and Environmental Health, part A 84:313-330. 2021.

• Risk assessment of unintentional phthalates contaminants in cosmetics. Regulatory Toxicology and Pharmacology 115:104687. 2020.

• Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats. Archives of Toxicology 94:887-909. 2020.

• Para-phenylenediamine, an oxidative hair dye ingredient, increases thymic stromal lymphopoietin and proinflammatory cytokines causing acute dermatitis . Toxicological Research 36:329-336. 2020.

• Novel functions for 2-phenylbenzylimidazole-5-sulphonic acid: Inhibition of ovarian cancer cell responses and tumor angiogenesis. Journal of Cellular and Molecular Medicine 24:2688-2700. 2020.

• Estrogen deficiency potentiates thioacetamide-induced hepatic fibrosis in Sprague-Dawley rats. International Journal of Molecular Sciences 20:3709. 2019.

• Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats. Laboratory Animal Research 35:9. 2019.

• Risk assessment of volatile organic compounds (VOCs) detected in sanitary pads.Journal of Toxicology and Environmental Health, part A 82:678-695. 2019.

• The relationship between epidermiology factors and usage pattern of hair care products in Korea. Annals of Dermatology 31:307-314. 2019.

• Possible effects of radiofrequency electromagnetic field exposure on central nerve system. Biomolecules & Therapeutics 27:265-275. 2019.

• Risk assessment of triclosan, a cosmetic preservative. Toxicological Research 35:137-154. 2019.

• Risk assessment of ethylhexyl dimethyl PABA in cosmetics..Toxicological Research 35:131-136. 2019.

• Risk assessment of drometrizole, a cosmetic ingredient used as an ultraviolet light absorber. Toxicological Research 35:119-129.. 2019.

• Risk assessment of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) used as a preservative in cosmetics. Toxicological Research 35:103-117. 2019.

• Effect of combined exposure to EDTA and zinc pyrithione on pyrithione absorption in rats. Toxicological Research 35:155-160. 2019.

• Perspectives on trace chemical safety and chemophobia: risk communication and risk management. Journal of Toxicology and Environmental Health, part A 82:186-199. 2019.

• The relationship between epidermiology factors and usage pattern of hair care products in Korea. Annals of Dermatology 31:307-314. 2019.

• 1H NMR toxicometabolomics following cisplatin-induced nephrotoxicity in male rats. The Journal of Toxicological Sciences 44:57-71. 2019.

• Serum and urine toxicometabolomics following gentamicin-induced nephrotoxicity in male Sprague-Dawley rats. Journal of Toxicology and Environmental Health, part A 81:408-420. 2018.

• Non-cancer, cancer, and dermal sensitization risk assessment of heavy metals in cosmetics. Journal of Toxicology and Environmental Health, part A 81:432-452. 2018.

• Risk assessment of N-nitrosodiethylamine (NDEA) and N-nitrosodiethanolamine (NDELA) in cosmetics. Journal of Toxicology and Environmental Health, part A 81:465-480. 2018.

• Analytical method development of methylisothiazolinone, a preservative, in rat plasma using LC-MS/MS. Journal of Chromatography B Analyt Technol Biomed Life Sci 1100-1101:27-32. 2018.

• Determination of fragrance allergens and their dermal sensitization quantitative risk assessment (QRA) in 107 spray perfumes. Journal of Toxicology and Environmental Health, part A 81:1173-1185. 2018.

• Effects of several cosmetic preservatives on ros-dependent apoptosis of rat neural progenitor cells. Biomolecules & Therapeutics 26:608-615. 2018.

• Efficient transdermal delivery of DNA nanostructures alleviates atopic dermatitis symptoms in NC/Nga mice. Advanced Functional Matrials 28:1801918. 2018.

• Reversed-phase high-performance liquid chromatographic method for the determination of permaton Red (D&C Red No.36) in cosmetics. Bulletin Of The Korean Chemical Society 39:1219-1222. 2018.

• Phloxine O, a cosmetic colorant, suppresses the expression of thymic stromal lymphopoietin and acute dermatitis symptoms in mice. Biomolecules & Therapeutics 26:481-486. 2018.

• Metabolic profiling of eccentric exercise-induced muscle damage in human urine. Toxicological Research 34:199-210. 2018.

• IL-1 and IL-1 as alternative biomarkers for risk assessment and the prediction of skin sensitization potency. Journal of Toxicology and Environmental Health, part A 81:830-432. 2018.

• Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens. Journal of Toxicology and Environmental Health, part B 20(3):155-182. 2017.

• Analysis of metabolomic patterns in thoroughbreds before and after exercise. Asian-Australasian Journal of Animal Sciences 30:1633-1642. 2017.

• Assessment of exposure for baby cosmetic care products in a Korean population. Food and Chemical Toxicology 106:107-113. 2017.

• Safety Evaluation of Polyethylene Glycol(PEG) compouds for Cosmetic Use.Toxicological Research 31(2):105-36. 2015.