▣ 피부흡수도 평가
▶ In vitro 피부투과실험을 통해 위해물질의 피부투과율 예측하고 독성연구에 기초자료로 활용한다.
◈ 서비스 절차
① 담당자와 면담 (전화) 후 샘플 의뢰 (샘플 종류 및 분석 조건등)
② 물질 분석 조건 확립 (약 2주)
③ 피부 투과 실험 진행 (약 2주)
④ 피부 투과 결과 보고서 작성 (약 1주)
◈ 관련논문
① Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition. Toxicological Research 39: 231-238. 2023.
② Toxicokinetics, Percutaneous Absorption and Tissue Distribution of Benzophenone‐3, an UV Filtering Agent, in Rats. Toxics 10: 672. 2022.
③ Analytical Method Development and Dermal Absorption of Pyrogallol, a Hair Dye Ingredient.
Toxics 10: 570. 2022.
④ Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats. Toxics 10: 329. 2022.
⑤ Effects of application amounts on in vitro dermal absorption test using caffeine and testosterone. Pharmaceutics 13:641. 2021.
⑥ Analytical method development and percutaneous absorption of propylidene phthalide, a cosmetic ingredient. Journal of Toxicology and Environmental Health, part A 84:811-820. 2021.
⑦ Effect of combined exposure to EDTA and zinc pyrithione on pyrithione absorption in rats. Toxicological Research 35:155-160. 2019.
⑧ Percutaneous permeability of 1-phenoxy-2-propanol, a preservative in cosmetics. Regulatory Toxicology and Pharmacology 103:56-62. 2019.
⑨ Analytical method development of methylisothiazolinone, a preservative, in rat plasma using LC-MS/MS. Journal of Chromatography B Analyt Technol Biomed Life Sci 1100-1101:27-32. 2018.
⑩ Percutaneous Absorption, Disposition, and Exposure Assessment of Homosalate, a UV Filtering Agent, in Rats. Journal of Toxicology and Environmental Health, Part A. 77(4):202-13. 2014.
⑪ HPLC-MS/MS method for the pharmacokinetics of homosalate after topical administration in rats. Journal of Liquid Chromatography & Related Technologies . 2465-2477. 2014.